117P Age and ovarian function influence on fertility preservation attitude and outcome in breast cancer patients

A significant increase in breast cancer (BC) rates has been observed among pre-menopausal woman. Considering the higher number of patients (pts) who have not completed their family planning and impact age on fertility, fertility preservation (FP) is proving to be a major challenge. Gemme Dormienti Onlus (GD) an italian association that helps pts by promoting valid model FP counselling. Our aim was identify influence ovarian function (OF) BC pts. We analyzed 100 referred GD. Pts were stratified 3 groups: group 1 (G1) 18-29 years (y) (N= 15), 2 (G2) 30-35 y (N=39), (G3) 36-39 (N=46). All underwent basal laboratory instrumental tests. options gonadotropin-releasing hormone agonists (GnRHa) and/or cryopreservation oocyte tissue (OTC). Basal follicle-stimulating (FSH), anti-Müllerian (AMH) 17 beta-estradiol (E2) variations affected woman all groups [FSH (mU/ml): G1=3.6 (2.8-9.1), G2= 5.6 (1.5-12.4); G3= 5.9 (1.8-12.2); p= 0.323], [AMH (ng/ml): G1=6.0 (2.4-9.4); 2.9 (1.0-7.6); 4.0 (1.0-8.1); 0.099], [E2 (pg/ml): G1=89.0 (58.0-133.0), 72.5 (11.0-511.3), 50.8 (10.0-314.3), p=0.248]. Age-associated changes antral follicular count (AFC) endometrial thickness (ET) clearly evident [Left-right AFC: G1=7.0 ± 3.1, 7.0 5.3; 2.5; 3.5 2.5, 3.0 4.2; p=<0.001, p=0.022], [ET (mm): G1=11.0 2.9; 9.0 3.1; 6.5 3.0; 0.022]. GnRHa treatment, 30 (G1=40%, 36.8%, G3=21.7%; 0.219); 18 OTC (G1=46.7%, G2=13.2%, G3=13%; p=0.008), 5 both techniques (G1=26.6%, G3=2.1). Lack time (G2=15.8%; G3=12.9%), contraindications (G1=66.7%; 47.4%; 51.6%) patient choice (G1=33.3%; 36.8%; 35.5%) main reasons for starting FP. 6 post-therapies pregnancies: spontaneous G3 4 induced, G2 from cryopreservation. data showed counseling crucial need premenopausal express realize desire pregnancy improve better quality life.